Well not sure about Titanium, I've got regular MW2 installed on a 98se box with a V5 though and it's working just fine. Using Amigamerlin 2.9 drivers and DirectX 8.1 for it and seems ok. I don't have any of the expansions for it so I can't test those individually but I wouldn't have thought that they changed any of the coding in there to not have it work the same way. If you need anything else, card settings or what not, I can give you how I'm running it, don't know if it'll help or not. The only thing I really have changed from the default settings is the AA to 4X and V-sync off, everything else I have left default.